I-Sodium Hyaluronate API kokubili izinhlelo zokusebenza ze-Injection kanye ne-Eyedrop

Igama Lomkhiqizo: I-Sodium Hyaluronate/I-Hyaluronic Acid

I-CAS: 9067-32-7

Ukuhlolwa: 95.0%～105.0%

Ukuqina Kwangaphakathi: Inani elilinganisiwe m³/kg

Isisindo sama-molecule: 800-3 million Da

Umsebenzi: I-Sodium Hyaluronate isetshenziswe kabanzi embonini ye-nutraceuticals. Ingagaywa futhi imuncwe, okwenza isikhumba sibe manzi, sibushelelezi, sithambe futhi sinwebeke; ibambezela ukuguga futhi ivimbele ukwenzeka kwe-arthritis kanye ne-brain atrophy I-Sodium hyaluronate iyi-glycosaminoglycan eyingxenye ebalulekile yesakhiwo se-cartilage yamalunga futhi inesibopho se-viscosity (ukujiya) koketshezi lwe-synovial. Sinezinhlobonhlobo ze-Sodium Hyaluronate ezivela ku-800-300W mocelur weight ongakhetha kuzo ukusebenzisa imikhiqizo ehlukene.

Isikhathi sokuphelelwa yisikhathi: iminyaka engu-2

Xhumana nathi

imininingwane yomkhiqizo

I-Hyaluronic acid, eyaziwa nangokuthi i-hyaluronan, i-HA kanye ne-uronic acid, iyi-polysaccharide eqondile eyakhiwe amayunithi e-disaccharide aphindaphindayo e-D-glucuronic acid kanye ne-N-acetyl-glucosamine.

Ayinamatheliswanga noma ihlanganiswe ndawonye namaprotheni, kodwa ikhona ngesimo sezinhlanganisela ezikhululekile noma ezingezona ezihlanganisa ndawonye. Isakhiwo sayo silula kodwa isisindo sama-molecule sikhulu kakhulu.

Ukucaciswa Kwebanga Le-MTOE.

Ukucaciswa Kwebanga Le-MTOE

Izinto Zokuhlola	Okujwayelekile	Izinto Zokuhlola	Okujwayelekile
Ukubukeka	Impuphu noma i-granule emhlophe noma ecishe ibe mhlophe	Insimbi/（mg/kg）	≤ 80
Ukuhlonza	A. I-spectrophotomet yokumuncwa kwe-infrared	Inani lamagciwane/（CFU/g）	≤100
	B. Inikeza ukusabela (a) kwe-sodium	Izikhunta kanye nemvubelo （CFU/g）	≤50
Ukulahlekelwa ekomiseni	≤15.0%	I-Staphylococcus aureus/g	Okubi
Ukuqina kwangaphakathi/	Inani elilinganisiwe	I-Pseudomonas aeruginosa/g	Okubi
（m³/kg）
Isisindo sama-molecule/（Da）	Inani elilinganisiwe	Ama-endotoxin ebhaktheriya/（IU/mg）
i-pH	5.0-8.5	I-Hemolysis	Okubi
I-Nucleic Acid	A260nm≤ 0.5	I-streptococci ye-Hemolytic	Okubi
Ukubonakala kwesisombululo	I-A600nm≤ 0.01	Izinsalela ze-ethanol/（ppm）	≤4000
Amaprotheni/%	≤0.1	I-sodium hyaluronate/（%）	95-105
Ama-chloride/%	≤ 0.5	/	/

Isicelo

1. Ukuhlinzwa Kwamehlo

Kuvikela amaseli e-endothelial e-cornea ekulimaleni kwemishini yokuhlinzwa

Gcina ukujula nesimo segumbi lamehlo elingaphambili ukuze kube lula ukuhlinzwa

Inikeza insimu ecacile yokuhlinzwa kudokotela ohlinzayo

Inikeza isikhala esibonakalayo esilula ukubekwa kwesithako esifakiwe

2. I-Cartilage Ehlanganisiwe

Ukugcoba, kunciphisa ukungqubuzana

Vimbela ukuwohloka kwe-cartilage, vikela i-cartilage, futhi ukhuthaze ukwakheka kwe-cartilage

Ukuvala umuzwa we-membrane, ukuqeda ubuhlungu

Ilawula ukusebenza kwamaseli futhi ivimbela i-angiogenesis

3. Ukwelapha Amanxeba

I-HA isheshisa izinga lokufuduka kwamaseli e-epithelial alimele futhi ikhuthaza ukufuduka kwama-macrophage adingekayo ekwelapheni amanxeba.

I-HA iphinde ithuthe amaprotheni athile nama-peptide afana nezinto zokukhula ziye ezingxenyeni zenxeba, okudlala indima ebalulekile ekwelapheni inxeba.