The beginning and end of the research on the Jinming Film, a good formula for protecting the voice

In 1983, the Health Department of Shandong Province instructed the Jinan Traditional Chinese Medicine Factory (now Hongjitang Pharmaceutical) to develop a medicine for treating and protecting the throat. Jinming tablets started research and development in 1987, and devoted themselves to it. Finally, they were successfully developed in June 1990 and obtained the national new drug certificate and approval number in 1991. They were put into the market in 1992. Subsequently, in May 1994, Jinming tablets won the first prize of Jinan Science and Technology Progress Award.

Jinming tablets belong to famous prescriptions, carefully developed based on the theory of strengthening the body and strengthening the foundation of traditional Chinese medicine. They have both classic formulas from the Ming and Qing dynasties and modern famous prescriptions. In the "Certificate of Identification of Scientific and Technological Achievements" of Jinming Film, there is a record that: "Based on traditional Chinese medicine prescriptions, the" Tie Di Wan "from Gong Tingxian's" Shoushi Baoyuan "in the Ming Dynasty," Bing Bo San "from Chen Shigong's" Surgical Authenticity ", and" Zeng Ye Tang "from Wu Jutong's" Wen Bing Tiao Bian "in the Qing Dynasty were used as the basis for the prescription of essential medicines. Jinming Film also accepted the throat preservation medication of Chinese Peking Opera master Mei Lanfang's former healthcare physician Zheng Zhi, combined with years of clinical trials and reforms to the dosage form, and finally developed Jinming Film. Before its production, it underwent strict and systematic pharmaceutical, pharmacological, toxicological, animal experimental, and clinical research. The sentence is:. The following groups of studies are documented in the literature. On January 30, 1989, the pharmacodynamics research was completed in Mount Taishan Medical College. The conclusion drawn from the anti-inflammatory experiment of Jinming tablets is that, according to preliminary clinical observations, Jinming tablets have good therapeutic effects on symptoms such as acute and chronic pharyngitis, vocal cord inflammation, sore throat, and hoarseness. At the same time, in antibacterial experiments, it was also confirmed that Jinming tablets have certain antibacterial effects. On February 10 of the same year, Jinming Tablets completed the toxicology study in the Pharmacology Teaching and Research Section of Mount Taishan Medical College. All personnel are researchers from the Pharmacology Teaching and Research Department of Shandong University School of Medicine. By establishing various mouse experiments related to throat diseases, the following conclusions were drawn: the maximum oral tolerance of mice exceeded 5.12 g/kg (436 times the daily dose for humans), indicating that the drug is relatively safe; No acute poisoning symptoms were found for 7 consecutive days; For 30 consecutive days, no signs of accumulation toxicity were found. Long term toxicity experiments were conducted for 75 consecutive days, and there were no significant differences in red and white blood cell counts, alanine aminotransferase, and urea nitrogen detection before and after administration.

In 1991, researchers from the Pharmacology Laboratory conducted experimental animal inflammation experiments on Jinming tablets. The effect of Jinming tablets on experimental inflammation of the vocal cords in rabbits induced by croton oil was observed by locally rubbing the vocal cords. The results showed that a 2% soybean oil solution had a significant inflammatory effect on the vocal cord tissue of rabbits, and its effect was stable. Jinming tablets can significantly counteract the inflammatory effects of croton oil, indicating the reliability of the indicators.

After animal experiments, enter clinical research. The research team recruited people from different professions and recorded their use of Jinming tablets. Through rigorous estimation and data analysis, the effective rate of Jinming tablets on symptoms such as pain, dryness, burning, itching, sputum, foreign body sensation, swelling, and hoarseness in acute and chronic pharyngitis and other diseases was over 80%. The efficacy of Jinming tablets on symptoms such as pain, dryness, burning, itching, and foreign body sensation was particularly outstanding, but there was no significant difference compared with the positive control group. There is a significant difference in the decrease of white blood cells between the experimental group and the positive control group, indicating that Jinming tablets have a certain anti-inflammatory effect.

For more than 30 years, as the exclusive product of Hongjitang Pharmaceutical and the national protected variety of traditional Chinese medicine, Jinming Tablet has not only been widely welcomed, but also won the annual scientific and technological progress award of the Ministry of Culture, the "eighth five-year" scientific and technological progress special contribution award of Shandong pharmaceutical industry, the first prize of Jinan Science and Technology Progress Award, and the excellent traditional Chinese patent medicines and simple preparations award. It has been recognized as a famous brand in Jinan, becoming a shining card of Hongjitang Pharmaceutical.